An extreme case of this is Li Fraumeni syndrome, where a genetic a defect in p53 leads to a high frequency of cancer in affected individuals.
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Block trades tend to cause the stock in question to decline, so knowing about one ahead of time can help an investor gain on a short sale or avoid a loss by unloading shares that are already owned.
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Cancer is a disease where regulation of the cell cycle goes awry and normal cell growth and behavior is lost.
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